For example: Agilent E4440A or Anritsu 68369
Nanovolt Preamp Option
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Keithley Instruments 1801 Overview
With just 0.6nV p-p noise, the Keithley Model 1801 Nanovolt Preamp for the Model 2001 and 2002 is the most sensitive room temperature digital nanovoltmeter available. But it's equally suitable for a wide range of low-level AC voltage, 4-wire ohms, frequency/period, and differential temperature measurement applications. It extends the low-level measurement ranges and amplifies the voltage sensitivity of the Model 2001 and 2002 DMMs by 1000 times.